Effect of a Simulated Weightlessness Model on the Production of Rat Interferon
- 1 January 1982
- journal article
- research article
- Published by Mary Ann Liebert Inc in Journal of Interferon Research
- Vol. 2 (4) , 467-470
- https://doi.org/10.1089/jir.1982.2.467
Abstract
A rat model simulating some aspects of weightlessness was used to determine whether simulated weightlessness might alter interferon production. The optimum time for in-vivo induction of alpha/beta interferon (α/β-IFN) by polyriboinosinic-polyribocytidylic acid was determined to be four hours in normal, mature rats. Rats suspended in the model for two weeks were injected with polyriboinosinic-polyribocytidylic acid and bled four hours later. A dramatic decrease (80%) in α/β-IFN production was observed in those animals exposed to simulated weightlessness as compared to control rats. These data suggest that weightlessness may alter certain immunological functions.Keywords
This publication has 10 references indexed in Scilit:
- Model for antiorthostatic hypokinesia: head-down tilt effects on water and salt excretionJournal of Applied Physiology, 1980
- The role of interferon in viral infectionsSpringer Seminars in Immunopathology, 1979
- Production, purification and characterization of rat interferonArchiv für die gesamte Virusforschung, 1979
- Spaceflight and Bone Turnover: Correlation with a New Rat Model of WeightlessnessBioScience, 1979
- On the varied biologic effects of interferonCellular Immunology, 1977
- Antitumor Effects Of InterferonPublished by Elsevier ,1973
- Stimulation or inhibition of interferon production depending on time of cycloheximide administrationVirology, 1970
- Inhibition of TRIG Agents by Virus-Induced Interferon.Experimental Biology and Medicine, 1966
- Virus interference. I. The interferonProceedings of the Royal Society of London. B. Biological Sciences, 1957