Factors Influencing Collateral Blood Flow to the Dog's Lung

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Abstract
The collateral circulation of the lung, i.e., that part of the bronchial flow which drains into the pulmonary veins, was studied by a heart-lung arrangement in which the lesser and systemic circuits of dogs could be perfused separately. In this preparation the collateral supply amounted to 0.5 to 1 per cent of the total arterial flow under approximately normal conditions. The changes in this collateral flow under a variety of experimental conditions were studied. These included variable systemic, venous and pulmonar pressures, lung collapse, air embolism, and actions of CO2 and serotonin.