THE EFFECT OF EXERCISE ON RENAL PLASMA FLOW IN NORMAL MALE SUBJECTS

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Abstract
Renal plasma flow was estimated from p-aminohippurate clearance in 9 healthy men aged 21 -32 yrs. A mechanical constant injn. apparatus was used and urine specimens were collected by voluntary micturition. In 59 expts., providing 140 clearance periods, the basal mean for consecutive detns. in triplicate was 613[plus or minus]107 cc. per min., corrected to 1.73 sq. m. body surface. Variability was analyzed into interindividual, intra-individual, and random components. During the first 16 mins. of walking on a motor-driven treadmill the renal plasma flow was decreased by an avg. of 6, 17, and 25% (of the resting control) at work levels, respectively, of 3 m.p.h. on the level, 3 m.p.h. at 5% grade, and 3.5 m.p.h. at 10% grade. Continued walking for another 16 min. yielded corresponding avg. reductions of 15, 27, and 35% of the resting control values. Return of the renal plasma flow to basal levels was incomplete after 40 min. of recovery following the exercise.