24-Hydroxylation of 25-Hydroxyvitamin D 3 : Is It Required for Embryonic Development in Chicks?
- 30 July 1982
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 217 (4558) , 451-452
- https://doi.org/10.1126/science.6979782
Abstract
As shown previously, laying hens given 1,25-dihydroxyvitamin D3 as their sole source of vitamin D produce fertile eggs having normal shells, but only 35 to 55 percent of the embryos are normal. Giving these hens additional 25-hydroxyvitamin D3, 24,25-dihydroxyvitamin D3, or 24,24-difluoro-25-hydroxyvitamin D3 at 1.25 nanomoles per day resulted in 90 to 100 percent normal embryos, and hence, hatchability. Since 24,24-difluoro-25-hydroxyvitamin D3 cannot be 24-hydroxylated, 24-hydroxylation is not required for this function of 25-hydroxyvitamin D3.Keywords
This publication has 10 references indexed in Scilit:
- Determination of vitamin D and its metabolites in plasma from normal and anephric manBiochemical Journal, 1979
- 24, 25-Dihydroxyvitamin D is a metabolite of vitamin D essential for bone formationNature, 1978
- Vitamin D: Two Dihydroxylated Metabolites Are Required for Normal Chicken Egg HatchabilityScience, 1978
- The Essentiality of Vitamin D Metabolites for Embryonic Chick DevelopmentScience, 1978
- Inhibition of Parathyroid Hormone Secretion by 25-Hydroxycholecalciferol and 24,25-Dihydroxycholecalciferol in the DogJournal of Clinical Investigation, 1978
- Vitamin D and boneMetabolic Bone Disease and Related Research, 1978
- Basic and Clinical Concepts Related to Vitamin D Metabolism and ActionNew England Journal of Medicine, 1977
- Basic and Clinical Concepts Related to Vitamin D Metabolism and ActionNew England Journal of Medicine, 1977
- Response of Chick Parathyroid Glands to the Vitamin D Metabolites, 1,25-Dihydroxycholecalciferol and 24,25-DihydroxycholecalciferolJournal of Nutrition, 1977
- Metabolism and Mechanism of Action of Vitamin DAnnual Review of Biochemistry, 1976