4p trisomy syndrome: Report of 4 additional cases and segregation analysis of 21 families with different translocations
- 1 January 1979
- journal article
- case report
- Published by Wiley in American Journal of Medical Genetics
- Vol. 4 (3) , 219-229
- https://doi.org/10.1002/ajmg.1320040304
Abstract
Thirty reports of partial 4p trisomy have been published. The manifestations and cytogenetic findings in four additional cases from two families are described in the present paper. Segregation analysis has been performed on the 21 families reported to date. The risk of having unbalanced offspring was the same in carrier mothers and carrier fathers. The risk of trisomic offspring was 14%. Among phenotypically normal progeny, normal karyotypes and balanced translocation states occurred with about equal frequency.Keywords
This publication has 15 references indexed in Scilit:
- Trisomy 4p and Deletion 4p- in a Family having a Translocation, t(4p-; 12p+)Human Heredity, 1978
- The trisomy 4p syndrome: Case report and reviewAmerican Journal of Medical Genetics, 1977
- Trisomy 4p due to a paternal t(4p-;16p+) translocationHuman Genetics, 1976
- Two cases of trisomy 4p with translocation t(4p-,7q+) in several members of one familyHuman Genetics, 1976
- Centric fission of chromosome No. 4 in the mother of two patients with trisomy 4pHuman Genetics, 1976
- A family with an inherited translocation involving the no. 4/no. 21 chromosomes.Journal of Medical Genetics, 1975
- Trisomy 4p14 ? 4pter with translocation t(4;15)(p14;p12) in the fatherPublished by Springer Nature ,1975
- Multiple congenital defects associated with trisomy for the short arm of chromosome 4Journal of Medical Genetics, 1974
- FAMILIAL 4/22 TRANSLOCATION WITH PARTIAL TRISOMY FOR THE SHORT ARM OF CHROMOSOME 4 IN TWO SIBSActa Paediatrica, 1974
- A 4–5/21–22 Chromosomal Translocation Associated with Multiple Congenital Anomalies1Acta Paediatrica, 1964