Proton nuclear magnetic resonance spectroscopy measurements of methylene and methyl line widths in plasma: Significant variations with extent of breast cancer, duration of pregnancy and aging

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Abstract
The composite methylene (chemical shift range 1.2-1.4 ppm) and methyl (0.8-0.9 ppm) resonances of the 1H NMR spectrum were analyzed in plasma samples from breast tumor patients, pregnant women, and healthy subjects. Using a 500 MHz NMR instrument operating at 25 °C, the peaks were analyzed for line width at half height and then averaged. A statistically significant difference (ppp = 0.022). In 54 healthy male and 130 healthy female controls, line widths declined gradually with increasing age by decades, except in the fifth decade for the men and the sixth decade for the women. The observations are consistent with an association between ‘stage’ in a most general sense and the apparent NMR lipid line widths, probably accounted for by a variation in plasma lipids.