NEUROHYPOPHYSIAL HORMONES AND RELEASE OF GONADOTROPHINS

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Abstract
SUMMARY: The gonadotrophin-releasing activity of hypothalamo-neurohypophysial hormones has been investigated in normal female rabbits. Pooled urine, obtained before and after intravenous injection of different posterior pituitary preparations (Pitressin, Pitocin, lysine-vasopressin and synthetic oxytocin), was extracted by the kaolin-acetone method and assayed by the mouse uterus test. All the posterior pituitary preparations used induced a significant rise in the release of gonadotrophins. The experiments suggest that posterior pituitary polypeptides may play a role in the physiological regulation of gonadotrophin release.