Role of genetic polymorphisms in tumour angiogenesis
Open Access
- 29 October 2002
- journal article
- review article
- Published by Springer Nature in British Journal of Cancer
- Vol. 87 (10) , 1057-1065
- https://doi.org/10.1038/sj.bjc.6600625
Abstract
Angiogenesis plays a crucial role in the development, growth and spread of solid tumours. Pro- and anti-angiogenic factors are abnormally expressed in tumours, influencing tumour angiogenesis, growth and progression. Polymorphisms in genes encoding angiogenic factors or their receptors may alter protein expression and/or activity. This article reviews the literature to determine the possible role of angiogenesis-related polymorphisms in cancer. Further research studies in this potentially crucial area of tumour biology are proposed.Keywords
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