TRANSMISSION OF MURINE LEUKEMIA-VIRUS (SCRIPPS) FROM PARENT TO PROGENY MICE AS DETERMINED BY P30 ANTIGENEMIA

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 36  (4) , 1228-1232
Abstract
All mice of C57BL/St, C3H/St, BALB/cSt, NZB/Scr and NZW/Lac strains developed high levels of p30 antigenemia after inoculation at birth with murine leukemia virus (Scripps). Transmission of virus from neonatally infected parents to their progeny for 3 successive generations, as evidenced by development of p30 antigenemia, varied among the 5 strains. Through the 3 generations, 100% transmission occurred in C3H/St and BALB/cSt mice, 50 to 61% transmission occurred in C57BL/St and NZW/Lac mice, and 11% transmission to the 1st generation, with no subsequent transmission, occurred in the NZB/Scr mice. Transmission appeared to occur readily via the milk in all strains. Intrauterine events also played a role with evidence of some viral transfer prior to birth in the C3H/St strain or, conversely, the development of resistance to infection prior to birth in C57BL/St mice. The occurrence of litters from infected parents containing both normal offspring and offspring with elevated p30 appeared to be the result of variable resistance in the intact offspring, perhaps as a result of intrauterine events, and not related to cellular resistance observable in tissue culture or to dominant genetic factors.