Evaluation of Antifungal Agents for Endodontic Use

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Abstract
This study investigated the antifungal properties of a number agents and also studied their potential irritating properties on tissue. For screening, the paper disc method was used to weed out the less effective agents. An end-point study was made of the more promising chemical agents by the tube dilution method. Those which were highly effective were injected subcutaneously (0.1 ml) into guinea pigs to determine their irritating potential. Sterile saline was used as a control. Each test was repeated at least 10 times. Thirty-five chemical agents, including antibiotics, were tested by the paper disc method against Candida albicans. They varied greately in effectiveness. Nifuroxime, chlorquinaldol, amobam, chlorphenol-champhor and metacresyl acetate were effective but the latter 2 could not be tested by tube-dilution because they are oily in nature. The most promising by the end-point method were niluroxime, bradosol, caprylate sodium, episol hydrochloride and episol tartrate. When examined for irritating properties in comparison with sterile saline (0.85) only nifuroxime was found to be non-irritating.

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