Prolonged Adjuvant Chemotherapy in Breast Cancer: The Scandinavian Adjuvant Chemotherapy Study 2

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Abstract
Eleven hundred and sixteen primary female breast cancer patients received one short perioperative chemotherapy course. the node negative patients were randomised between immuno-therapy (corynebacterium parvum s.c. around the scar 2 weeks after mastectomy). or no further adjuvant therapy. A moderate, but significant delaying effect was observed, without side effects. the node positive patients were randomised to four groups: I) the same immunotherapy as in the node negative patients. 2) CMF for 1 year, 3) combination of these two treatments, or 4) no further adjuvant therapy. the prolonged chemotherapy had a significant positive effect, but also considerable and distressing side effects. the immunotherapy had a non-significant negative effect in the node positive patients, but without side effects.

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