Dramatic enhancement of the photoactivity of zinc porphyrin–ellipticine conjugates by DNA
- 1 January 1990
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 16,p. 1131-1133
- https://doi.org/10.1039/c39900001131
Abstract
Both the fluorescence yield and the yield of singlet oxygen generated from the quenching of the triplet state of two water-soluble hybrid molecules ‘zinc porphyrin-ellipticine’, (1) and (2), are low compared to those of simple zinc porphyrin complexes; both these photochemical properties are dramatically enhanced by addition of calf thymus DNA to solutions of (1) or (2), as a result of the conformation change of these hybrid molecules upon interaction with double-stranded nucleic acids.Keywords
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