Bastadin 20 and Bastadin O-Sulfate Esters from Ianthella basta: Novel Modulators of the Ry1R FKBP12 Receptor Complex
- 1 January 1996
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 59 (12) , 1121-1127
- https://doi.org/10.1021/np960507g
Abstract
New compounds bastadin 20 (9), 15,34-O-disulfatobastadin 7 (10), and 10-O-sulfatobastadin 3 (11) were isolated from Ianthella basta collected in Exmouth Gulf, Western Australia. Compounds 10 and 11 exhibited moderate differential activity as SR Ca2+ channel agonists (EC50 13.6 and 100 μM, respectively) of the Ry1R FKBP12 complex, while the potency of 9 was almost half that of 10 (EC50 20.6 μM). The problem of dereplication of bastadins was addressed using 1H-NMR “fingerprinting” of MeO signals in the corresponding permethyl bastadin derivatives.Keywords
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