A human T cell tumor which expresses the putative T cell antigen receptor

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Abstract
A monoclonal antibody (mAb) called H1‐2D4 which reacts only with the T cell line HPB‐ALL and not with other T cell lines, normal or activated peripheral blood cells, B lymphoblasts (B‐LCL), or thymocytes has been developed. This mAb cocaps the T3 antigen on HPB‐ALL and anti‐T3 mAb cocaps the antigen which reacts with H1‐2D4. Purified H1‐2D4 precipitates a heterodimer from HPB‐ALL cells which has components with molecular weights of 51000 and 39000. The properties of the molecule recognized by H1‐2D4 suggest that it is the HPB‐ALL equivalent of the putative human T cell antigen receptor.