ABNORMAL CONCENTRATION OF STABLE HBA1 IN NON-DIABETIC PATIENTS

  • 1 January 1984
    • journal article
    • research article
    • Vol. 10  (5) , 299-303
Abstract
To study its specificity for hyperglycemia, stable Hb A1 was determined with ion-exchange chromatography in 240 patients consecutively hospitalized in the department of internal medicine and in a nondiabetic reference population. Reference values were found to increase significantly with age in the age groups < 30, 30-60, and > 60 yr. Forty-one patients had stable Hb A1 more than 2 SD above the mean of the reference group and random blood glucose < 7 mmol/1, and 21 of these were classified as non-diabetics according to data in medical records. Four non-diabetic patients had stable Hb A1 higher than + 4 SD. One of them had hemoglobinopathia, 1 severe anemia under cortisone treatment, 1 cortisone treated myelomatosis with renal insufficiency and severe anemia, and 1 patient had lymphoma and renal insufficiency. Nine patients had stable Hb A1 between + 3 and 4 SD and diagnoses of coronary heart disease (4), rheumatoid arthritis (2), asthma (1), chronic renal failure (1) and malignant melanoma (1). Five of them were treated with cortisone or diuretics. Four patients had stable Hb A1 slightly below the reference range. In summary marked elevation of stable Hb A1 due to factors other than diabetes occurred in a few patients with hematological disorders.