The hippocampus is necessary for enhancements and impairments of learning following stress

30 September 2007

journal article
research article
Published by Springer Nature in Nature Neuroscience

Vol. 10 (11) , 1401-1403
https://doi.org/10.1038/nn1973

Abstract

The hippocampus is often considered to be an important site for stress and learning interactions; however, it has never been demonstrated whether these effects require the hippocampus. In the current study, hippocampal lesions prevented both enhancements of learning after stress in male rats and impairments of learning after stress in female rats without disrupting learning itself in either sex. Thus, the hippocampus is necessary for modifying learning in males and females after acute stressful experience.

Keywords

This publication has 16 references indexed in Scilit:

Acute stress facilitates trace eyeblink conditioning in C57BL/6 male mice and increases the excitability of their CA1 pyramidal neurons
Learning & Memory, 2005
The bed nucleus of the stria terminalis is critically involved in enhancing associative learning after stressful experience.
Behavioral Neuroscience, 2005
Males and females respond differently to controllability and antidepressant treatment
Biological Psychiatry, 2004
AChE-stained horizontal sections of the rat brain in stereotaxic coordinates
Published by Elsevier ,2003
Glucocorticoids are necessary for enhancing the acquisition of associative memories after acute stressful experience
Hormones and Behavior, 2003
Stress and cognitive function
Published by Elsevier ,2002
Acute Stress Rapidly and Persistently Enhances Memory Formation in the Male Rat
Neurobiology of Learning and Memory, 2001
Stress-Induced Facilitation of Classical Conditioning
Science, 1992
Hippocampus and trace conditioning of the rabbit's classically conditioned nictitating membrane response.
Behavioral Neuroscience, 1986
Hippocampus and trace conditioning of the rabbit's classically conditioned nictitating membrane response.
Behavioral Neuroscience, 1986