Gentamicin-Resistant Bacillary Infection

Publisher Website
Google Scholar
Abstract
Infections caused by gentamicin sulfate-resistant Pseudomonas aeruginosa and Serratia marcescens have occurred in multiple areas of our hospitals and have caused serious clinical illness and death. Isolates of Pseudomonas organisms were sensitive to some alternative drugs including colistin sulfate, but isolates of Serratia organisms were often resistant to all commercially available parenteral antimicrobials. All isolates were inhibited by amikacin sulfate, and 95% were killed by concentrations achievable in serum with recommended doses. Twenty patients with hospital-acquired infections, including ten with septicemia, were treated with amikacin. Eighteen of the 20 patients had a good clinical and bacteriologic response. Ototoxicity and nephrotoxicity each occurred in one patient. (Arch Intern Med 138:201-205, 1978)

This publication has 6 references indexed in Scilit: