Cloning and characterization of the t(X;II) breakpoint from a leukemic cell line identify a new member of the forkhead gene family
- 1 October 1994
- journal article
- research article
- Published by Wiley in Genes, Chromosomes and Cancer
- Vol. 11 (2) , 79-84
- https://doi.org/10.1002/gcc.2870110203
Abstract
Chromosome translocations involving 11q23 are associated with a number of different types of leukemia. These translocations fuse a gene encoding a putative transcription factor, HTRXI, to genes on other chromosomes. We report cloning and sequencing the t(X;II) breakpoint region from a cell line established from an infant with acute lymphocytic leukemia. The gene AFXI, on the X chromosome, is expressed in a variety of cell types. Sequence analysis indicates a high degree of homology between AFXI and the forkhead family of transcription factors. The high degree of identity within the forkhead region and the lack of homology outside that region suggest that AFXI represents a novel forkhead family member. It is predicted that a chimeric fusion protein with altered DNA binding activity will be the result of the translocation.Keywords
This publication has 21 references indexed in Scilit:
- DNA-binding properties and secondary structural model of the hepatocyte nuclear factor 3/fork head domain.Proceedings of the National Academy of Sciences, 1993
- Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcomaNature Genetics, 1993
- Acute leukemias of different lineages have similar MLL gene fusions encoding related chimeric proteins resulting from chromosomal translocation.Proceedings of the National Academy of Sciences, 1993
- The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 geneCell, 1992
- A trithorax–like gene is interrupted by chromosome 11q23 translocations in acute leukaemiasNature Genetics, 1992
- HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24.Proceedings of the National Academy of Sciences, 1991
- Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head.Genes & Development, 1991
- The human t(1;19) translocation in pre-B ALL produces multiple nuclear E2A-Pbx1 fusion proteins with differing transforming potentials.Genes & Development, 1991
- A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B allCell, 1990
- The establishment and cytological, cytochemical and immunological characterisation of human haemic cell lines: Evidence for heterogeneityLeukemia Research, 1977