Mutations in the Reduced Folate Carrier Gene Which Confer Dominant Resistance to 5,10-Dideazatetrahydrofolate
Open Access
- 1 October 1998
- journal article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 273 (40) , 25953-25960
- https://doi.org/10.1074/jbc.273.40.25953
Abstract
No abstract availableKeywords
This publication has 18 references indexed in Scilit:
- Cellular Folates Prevent Polyglutamation of 5,10-DideazatetrahydrofolateJournal of Biological Chemistry, 1998
- A Reduced Folate Carrier Mutation Produces Substrate-dependent Alterations in Carrier Mobility in Murine Leukemia Cells and Methotrexate Resistance with Conservation of Growth in 5-FormyltetrahydrofolateJournal of Biological Chemistry, 1998
- Loss of Folic Acid Exporter Function with Markedly Augmented Folate Accumulation in Lipophilic Antifolate-resistant Mammalian CellsPublished by Elsevier ,1997
- Organization, structure and alternate splicing of the murine RFC-1 gene encoding a folate transporterGene, 1997
- A Phase I clinical study of the antipurine antifolate lometrexol (DDATHF) given with oral folic acidInvestigational New Drugs, 1996
- Characterization of a Mutation in the Reduced Folate Carrier in a Transport Defective L1210 Murine Leukemia Cell LinePublished by Elsevier ,1995
- Increased expression and characterization of two distinct folate binding proteins in murine erythroleukemia cellsBiochemical Pharmacology, 1994
- Determinants of the disparate antitumor activities of (6R)-5,10-dideaza-5,6,7,8-tetrahydrofolate and methotrexate toward human lymphoblastic leukemia cells, characterized by severely impaired antifolate membrane transportBiochemical Pharmacology, 1993
- Carrier-mediated transport of folate compounds in L1210 cellsBiochemical Pharmacology, 1987
- Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterinJournal of Medicinal Chemistry, 1985