Inositol 1,3,4,6-tetrakisphosphate mobilizes calcium in Xenopus oocytes with high potency
- 15 January 1991
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 273 (2) , 317-321
- https://doi.org/10.1042/bj2730317
Abstract
Injection of Ins(1,3,4,6)P4 into Xenopus oocytes evoked Ca2(+)-dependent membrane currents with a potency 5-10 times less than Ins(1,4,5)P3, whereas Ins(1,3,4)P3 and Ins(1,3,4,5,6)P5 were almost ineffective. Responses to Ins(1,3,4,6)P4 arose through liberation of intracellular Ca2+ and through entry of extracellular Ca2+. These results, together with the observation that Ins(1,3,4,6)P4 facilitated responses to Ins(1,4,5)P3, suggests that both of these compounds may act on the same intracellular receptors.Keywords
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