Mezlocillin Concentrations in Human Aqueous Humour after Intravenous and Subconjunctival Administration
- 1 January 1985
- journal article
- research article
- Published by S. Karger AG in Chemotherapy
- Vol. 31 (3) , 169-172
- https://doi.org/10.1159/000238331
Abstract
27 patients received either 4 g intravenous infusion 1–3 h or 100 mg subconjunctival application of mezlocillin 1–12 h before cataract extraction. After intravenous administration the mean aqueous humour concentration of mezlocillin was 2.9 μg/ml after 2 h. The subconjunctival dose produced a mean aqueous humour concentration of 23 and 2.6 μg/ml after 3 and 12 h, respectively. These levels are above the minimum inhibitory concentration of mezlocillin for sensitive organisms.Keywords
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