Role of Ebola Virus VP30 in Transcription Reinitiation
Open Access
- 15 December 2008
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 82 (24) , 12569-12573
- https://doi.org/10.1128/jvi.01395-08
Abstract
VP30 is a phosphoprotein essential for the initiation of Ebola virus transcription. In this work, we have studied the effect of mutations in VP30 phosphorylation sites on the ebolavirus replication cycle by using a reverse genetics system. We demonstrate that VP30 is involved in reinitiation of gene transcription and that this activity is affected by mutations at the phosphorylation sites.This publication has 21 references indexed in Scilit:
- Generation of biologically contained Ebola virusesProceedings of the National Academy of Sciences, 2008
- Ebola Virus VP30 Is an RNA Binding ProteinJournal of Virology, 2007
- Crystal structure of the C-terminal domain of Ebola virus VP30 reveals a role in transcription and nucleocapsid associationProceedings of the National Academy of Sciences, 2007
- Infection of Naïve Target Cells with Virus-Like Particles: Implications for the Function of Ebola Virus VP24Journal of Virology, 2006
- Ebola virus: unravelling pathogenesis to combat a deadly diseaseTrends in Molecular Medicine, 2006
- Phosphorylation of VP30 Impairs Ebola Virus TranscriptionJournal of Biological Chemistry, 2002
- Recovery of Infectious Ebola Virus from Complementary DNA: RNA Editing of the GP Gene and Viral CytotoxicityScience, 2001
- An Introduction to Ebola: The Virus and the DiseaseThe Journal of Infectious Diseases, 1999
- Differentiation of filoviruses by electron microscopyVirus Research, 1995
- Sequence analysis of the Ebola virus genome: organization, genetic elements, and comparison with the genome of Marburg virusVirus Research, 1993