Experimental mast cell activation improves connective tissue repair in the perforated rat mesentery
- 1 July 1991
- journal article
- Published by Springer Nature in Inflammation Research
- Vol. 33 (3-4) , 371-377
- https://doi.org/10.1007/bf01986588
Abstract
The participation of mast cells in connective tissue repair was studied using the perforated-rat-mesentery model. Perforation of mesenteric membranes was performed during laparotomy of anesthetized Sprague-Dawley rats. Laparotomy significantly reduced the histamine content of the mesenteric membranes on day 1 postoperatively and perforation as such reduced the histamine content even more on days 1–10. Mast cell activation induced by a single intraperitoneal injection of Compound 48/80 two days prior to operation, significantly improved healing on days 5–7 postoperatively. Daily injections of Compound 48/80 for 5 days prior to operation showed significantly better healing compared to such injections for five days postoperatively. Administration of lupitidine, a long acting histamine H2-receptor antagonist, two times daily starting on the day of 48/80 injection to day 4 after operation did not apparently affect healing. The results indicate that mast cells may be activated during normal wound healing and that a preoperative, pharmacological activation improves healing. Furthermore, histamine does not seem to be of major importance for the beneficial effect of such mast cell activation on connective tissue repair.Keywords
This publication has 33 references indexed in Scilit:
- Mitogenesis in wound‐healing cells in diabetic ratsAPMIS, 1988
- Effect of cimetidine on wound healing in ratsInflammation Research, 1986
- Compound 48/80 and the healing of wounds in rats. The effect of timing of drug injectionsInflammation Research, 1984
- TIME‐COURSE AND RATE OF HEALING AFTER WOUNDING THE AVASCULAR MESENTERY IN DIABETIC RATSActa Pathologica Microbiologica Scandinavica Series A :Pathology, 1984
- A TISSUE MODEL FOR QUANTITATIVE STUDIES ON TIME COURSE OF HEALING, RATE OF HEALING, AND CELL PROLIFERATION AFTER WOUNDINGActa Pathologica Microbiologica Scandinavica Series A :Pathology, 1983
- FURTHER STUDIES ON THE RELATIONSHIP BETWEEN DRUG‐INDUCED MAST‐CELL SECRETION AND LOCAL CELL PROLIFERATIONActa Pathologica Microbiologica Scandinavica Section A Pathology, 1981
- LOCAL MITOGENIC EFFECT OF TISSUE MAST CELL SECRETIONCell Proliferation, 1980
- Mast Cell Analyses in Hypertrophic Scars, Hypertrophic Scars Treated with Pressure and Mature ScarsJournal of Investigative Dermatology, 1978
- Influence of antihistamine and compound 48/80 on healingCellular and Molecular Life Sciences, 1975
- GRANULATION TISSUE AS A CONTRACTILE ORGANThe Journal of Experimental Medicine, 1972