Effects of Food Intake and Various Extrinsic Hormones on Portal Blood Flow in Patients with Liver Cirrhosis Demonstrated by Pulsed Doppler with the Octoson

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Abstract
In the fasting state the mean portal blood flow demonstrated by the pulsed Doppler system with the Octoson in liver cirrhosis (LC) patients (velocity (PV), 10.2 ± 3.5 (mean ± SD) cm/sec, 7.0 ± 2.6 cm/sec/m2; flow (PF), 579 ± 262 ml/min, 383 ± 184 ml/min/m2 (n = 40)) was significantly lower than that in control subjects (PV, 21.2 ± 5.2 cm/sec, 14.7 ± 3.9 cm/sec/m2; PF, 966 ± 344 ml/min, 667 ± 220 ml/ min/m2 (n = 40)). Food intake increased PV by 15% and PF by 15% in LC (n = 8) and increased PV by 56%, PF by 125% in controls (n = 8). Glucagon increased PV by 30% and PF by 52% in LC (n = 10) and increased PV by 50% and PF by 120% in controls (n = 8). Secretin increased PV by 44% and PF by 75% in LC (n = 9) and increased PV by 66% and PF by 142% in controls (n = 8). Vasopressin decreased PV by 42% and PF by 54% in LC (n = 9) and decreased PV by 48% and PF by 62% in controls (n = 8). Insulin, gastrin, and prostaglandin E1 had no effect in either group.

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