Optimization of the Production Process and Characterization of the Yeast-Expressed SARS-CoV Recombinant Receptor-Binding Domain (RBD219-N1), a SARS Vaccine Candidate
Open Access
- 26 April 2017
- journal article
- research article
- Published by Elsevier in Journal of Pharmaceutical Sciences
- Vol. 106 (8) , 1961-1970
- https://doi.org/10.1016/j.xphs.2017.04.037
Abstract
No abstract availableKeywords
Funding Information
- National Institutes of Health (R01AI098775)
This publication has 33 references indexed in Scilit:
- A simplePichia pastorisfermentation and downstream processing strategy for making recombinant pandemic Swine Origin Influenza A virus Hemagglutinin proteinJournal of Industrial Microbiology & Biotechnology, 2013
- A Double-Inactivated Severe Acute Respiratory Syndrome Coronavirus Vaccine Provides Incomplete Protection in Mice and Induces Increased Eosinophilic Proinflammatory Pulmonary Response upon ChallengeJournal of Virology, 2011
- Potent and persistent antibody responses against the receptor-binding domain of SARS-CoV spike protein in recovered patientsVirology Journal, 2010
- Diffusion and Sedimentation Interaction Parameters for Measuring the Second Virial Coefficient and Their Utility as Predictors of Protein AggregationBiophysical Journal, 2010
- A 219-mer CHO-Expressing Receptor-Binding Domain of SARS-CoV S Protein Induces Potent Immune Responses and Protective ImmunityViral Immunology, 2010
- High frequency of SEN virus infection in thalassemic patients and healthy blood donors in IranVirology Journal, 2010
- Recombinant receptor-binding domain of SARS-CoV spike protein expressed in mammalian, insect and E. coli cells elicits potent neutralizing antibody and protective immunityVirology, 2009
- Antigenicity and immunogenicity of SARS-CoV S protein receptor-binding domain stably expressed in CHO cellsBiochemical and Biophysical Research Communications, 2009
- The spike protein of SARS-CoV — a target for vaccine and therapeutic developmentNature Reviews Microbiology, 2009
- Enhancing the Production of Fc Fusion Protein in Fed-Batch Fermentation of Pichia pastoris by Design of ExperimentsBiotechnology Progress, 2008