Comparison of intra-arterial cis-diamminedichloroplatinum II with high-dose methotrexate and citrovorum factor rescue in the treatment of primary osteosarcoma.

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Abstract
A randomized 2-arm study was undertaken to determine relative tumoricidal effects of intra-arterial cis-diamminedichloroplatinum II (I/A-CDP) and high-dose methotrexate with citrovorum factor rescue (MTX-CF) in the treatment of the primary tumor in patients with osteosarcoma. Responses were evaluated by clinical, radiographic, angiographic and pathologic parameters. Patients (15) were randomized to receive MTX-CF and 15 to I/A-CDP. In the MTX-CF arm there were 4 responses (3 complete responses, 1 partial response) whereas in the I/A-CDP arm these were 9 responses (7 complete responses, 2 partial responses). Two patients who failed MTX-CF and requested alternative treatment with I/A-CDP also responded. The total I/A-CDP response was 11/17.