Influence of HLA-D/DR antigen disparity in CTL generation in vitro

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Abstract
This report describes the influence of HLA-D/DR antigen disparity upon the level of cytotoxicity in allogeneic in vitro cultures. Allogeneic cultures, between unrelated HLA-D/DR full house donors, tested in CML [cell-mediated lympholysis] gave 3 different levels of cytotoxicity, termed weak, intermediate and strong cytotoxicity. HLA-D/DR compatibility predicts weak cytotoxicity and 2 HLA-B antigen incompatibility predicts strong cytotoxicity. HLA-A antigens have no major influence upon the strength of cytotoxicity. Accepting that the MLC[mixed lymphocyte culture]/CML reaction is an in vitro parallel to the in vivo transplantation of allogeneic tissue, the observations are in accordance with the results of HLA-D/DR matching for graft survival in human renal transplantation.