Typing by cytotoxic lymphocytes. Genetics of HLA-non-A, B, C determinants-family studies

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Abstract
Some CTL [cytotoxic T lymphocytes] recognize HLA-structures in a different way than antibodies; they may identify other epitopes rather than antibodies or may define genetically distinct structures. From [human] population studies, in vitro educated CTL were selected giving rise to significant lysis on PHA[phytohemagglutinin]-lymphoblasts in the absence of the sharing HLA-A, B, (C) determinants between stimulator and target lymphocytes. Based on pair-wise correlations these CTL from 3 clusters, identifying structures associated to HLA-markers. Subsequent testing in 14 complete families of .gtoreq. 4 children allowed the following observations: CML[cell-mediated lympholysis]-traits assigned on the basis of single CTL often segregated in a non-mendelian way or independent of HLA; assignments made on the basis of CTL-clusters segregated with HLA; in 2 informative HLA-B/D, DR recombinant families, CML-traits segregated with HLA-B; no haplotype could be assigned more than 1 CML-trait.