An Unusual Cyclization of Trifluoroacetohydroximoyl and -hydrazonoyl Bromides with Malononitrile
- 1 December 1987
- journal article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 60 (12) , 4480-4482
- https://doi.org/10.1246/bcsj.60.4480
Abstract
Trifluoroacetohydroximoyl bromide etherate (1) reacted with an excess of malononitrile in the presence of sodium methoxide, giving a fused isoxazolopyridine 3, participated by two molecules of malononitrile, along with the conventional isoxazole 2. Similar concomitant formation of 7 and the fused pyrazolopyridines 8 was also recognized from the hydrazonoyl bromides 6 and their product ratio was found to depend on the reaction conditions, particularly on the concentration of malononitrile used.This publication has 8 references indexed in Scilit:
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