Effect of Chronic Use of Cyproterone Acetate on the Epididymis of Goat

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Abstract
Effect of chronic treatment of cyproterone acetate, (CA), an antiandrogen with antigonadotropin activity, on the epididymal sperm reserve and sperm maturation was studied in Black Bengal goats (a dwarf breed). This compound produced significant reduction in epididymal sperm numbers in the treated groups as compared to the controls. There was significant reduction in progressive sperm motility. Other morphological maturation changes like the length and breadth of the sperm head were significantly altered after treatment with CA for 70 days; a greater number of caudal spermatozoa of treated animals retained their cytoplasmic droplets than those of controls.