Postnatal changes in the localization of small intestinal NAD(P)H-dependent H2O2-generating enzyme activity in the rat.

Publisher Website
Google Scholar
Abstract
A glutaraldehyde-insensitive, NAD(P)H-dependent H2O2-generating enzyme activity in the rat small intestine and its regional differences in the small intestine of the adult rat were previously described. The postnatal changes of this enzyme activity in the small intestine were studied using 1-day to 6-mo.-old male Kyo-Wistar rats. The NAD(P)H-dependent H2O2-generating enzyme activity showed a marked postnatal change. The enzyme activity was significantly higher in the apical membrane of absorptive cells of both duodenojejunum and ileum in newborn rats, however the activity in the apical membrane of the ileum decreased from the 7th postnatal day on, eventually reaching an extremely weak activity as in the adult. The activity in the apical membrane of the duodenojejunum remained the same throughout the course of growth. These findings are discussed in connection with postnatal changes in absorptive function.