Development of Second Generation Monoclonal Antibodies Recognising Lewisyy/bAntigen by Anti-Idiotypic Immunisation
- 1 December 1993
- journal article
- research article
- Published by Mary Ann Liebert Inc in Hybridoma
- Vol. 12 (6) , 647-660
- https://doi.org/10.1089/hyb.1993.12.647
Abstract
Five new monoclonal antibodies (Mabs) recognising the Lewisy/b hapten of the IgG isotype have been produced following immunisation with rat anti-idiotypic antiserum to C14, an IgM Lewisy/b hapten Mab and boosting with C14gp200 antigen. They have the same fine specificity as the original Mab binding to a cell surface and secreted antigen preferentially expressed by colorectal tumour cells.Keywords
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