Effects of Trypan Blue on Hepatocarcinogenesis in Rats Given Ethionine or N-2-Fluorenylacetamide2

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Abstract
Commercial trypan blue and ethionine are mutually antagonistic in the induction of liver neoplasia in that trypan blue suppresses ethionine-induced hepatocellular carcinoma and ethionine suppresses trypan-blue-induced reticulum cell sarcoma. Trypan blue is considerably more effective when administered during the first 5 weeks than during weeks 8–13. In contrast, trypan blue has no apparent influence on liver carcinoma induced by N-2-fluorenylacetamide, while N-2-fluorenylacetamide suppresses sarcoma induction by trypan blue to an extent equal to that by ethionine. The mechanisms of these interactions are at present obscure.