Cationic Chlorophyl Derivatives with SOD Mimicking Activity Suppress the Proliferation of Human Ovarian Cancer Cells

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Abstract
Derivatives of chlorophyl, e.g. Fe-chlorin e6-Na, α, β, γ, δ-Tetraphenylporphine-tetrasulfonic acid disulfonic acid salt tetrahydrate (Fe-TPPTS) and α, β, γ, δ-Tetrakis (4-N-trimethylaminophenyl) porphine, tetra (ptoluensulfonate (Fe-TTMAPP), express SOD mimicking activity. Examination was made of suppressive effects of human cancer cell lines by derivatives of chlorophyl. Fe-TPPTS and Fe-TTMAPP suppressed proliferation of the human ovarian cancer cell lines but Fe-chlorin e6-Na failed to suppress the proliferation. Lipid peroxide was increased by application of Fe-TPPTS and Fe-TTMAPP, but decreased by application of Fechlorin e6-Na. SOD activity of the cancer cells did not change by application of these drugs. TPPTS and TTMAPP have a cationic charge but Fe-chlorin e6-Na has an anionic charge. It is suggested that charge of these drugs relates to the suppressive effeccts of the cancer cell proliferation.