Transient Depletion of T Cells with Bright CD11a/CD18 Expression from Peripheral Circulation during Acute Kawasaki Disease

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Abstract
To clarify the activation of peripheral blood T cells in Kawasaki disease (KD) patients, we investigated whether expression of lymphocyte function‐associated antigen‐1 (LFA‐1, CD11a/CD18) and/or intercellular adhesion molecule‐1 (ICAM‐1, CDS4) on peripheral blood T cells increases during the acute stage. Expression of cellular adhesion molecules was measured using flow cytometry. There was a decrease in the percentage of CD3+ T cells in the bright LFA‐1α and LFA‐1β population and a concomitant increase in the dim population of LFA‐1α and LFA‐1β during the acute stage, in comparison with those of the convalescent stage. In addition, we observed no significant differences in ICAM‐1 expression during the acute stage compared with that of the convalescent stage. In our view the present data, in conjunction with previous reports on T‐cell function during acute KD, suggest that activated T cells are temporarily withdrawn from peripheral circulation during acute KD.