A reciprocal autosomal translocation which causes male sterility in the mouse also impairs oogenesis
- 1 November 1985
- journal article
- research article
- Published by Bioscientifica in Reproduction
- Vol. 75 (2) , 647-652
- https://doi.org/10.1530/jrf.0.0750647
Abstract
A quantitative histological analysis of ovaries from 3- and 5-day-old female mice heterozygous for the male-sterile reciprocal autosomal translocation, T(11;19)42H, revealed a marked reduction (by 65%) in the number of oocytes as compared to controls. These findings call into question the widely held view that chromosomal anomalies causing spermatogenic failure have no effect on oogenesis. It is suggested that during meiosis in males and females there is a mechanism operating which tends to eliminate cells which had incomplete chromosome pairing at the pachytene stage.This publication has 5 references indexed in Scilit:
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