Peritoneovenous (LeVeen) shunt. Control of renin-aldosterone system in cirrhotic ascites

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Abstract
Because of the unusual clinical course of a patient with hepatic cirrhosis, refractory ascites and hepatorenal syndrome, the complex interrelationships between massive ascites, renin-aldosterone activity, and renal and hepatic function were examined before and after placement of a peritoneojugular vein (LeVeen) shunt. Measurements indicated that when the shunt was functioning, renin-aldosterone production was suppressed, the hepatorenal syndrome was reversed, and ascites remitted. Hyperreninemia, hyperaldosteronism and functional renal abnormalities of this disorder may be potentially reversible and arise primarily from the imbalance between formation and drainage of hepatosplanchnic lymph rather than from hepatocellular dysfunction, lowered plasma oncotic pressure, or portal hypertension.