THE METABOLISM OF ALDOSTERONE IN NORMAL SUBJECTS AND IN PATIENTS WITH HEPATIC CIRRHOSIS*
Open Access
- 1 August 1962
- journal article
- research article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 41 (8) , 1672-1680
- https://doi.org/10.1172/jci104624
Abstract
The intravenous administration of 7-H3-aldosterone to 16 normal subjects and 9 patients with hepatic cirrhosis revealed a slower rate of disappearance of aldosterone from the plasma in those with cirrhosis. In addition cirrhotic patients excreted in urine a greater proportion of the aldosterone in the form of the acid-hydro-lyzable conjugate and a lesser proportion as tetrahydroaldosterone. Orally administered aldosterone was shown to be ineffective in man because of rapid inactivation during a single passage through the liver.Keywords
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