Regulation of immune response to tumor antigen: interference with syngeneic tumor immunity by anti-IA alloantisera.

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Abstract
A role of I-A subregion-encoded determinants in syngeneic tumor immunity is shown. In animals rendered immune to the S1509a fibrosarcoma, daily treatment with microliter quantities of antisera directed against Kk and I-Ak determinants expressed on lymphoid cells of host origin decreased the capacity for immune tumor rejection. Absorption studies revealed that anti-I-Ak antibody activity alone was sufficient for the mainfestation of this effect. Experiments utilizing F1 hybrids showed that an antiserum that was genetically unable to interact with H-2 determinants expressed on the tumor was equally effective in inhibiting tumor immunity. The activity of this antiserum may be related to interference with the generation of effector T [thymus- derived] cell function. Hyperimmune animals pre-treated with an anti-Kk,I-Ak antiserum were no longer capable of adoptively transferring tumor immunity to naive recipients. The secondary immune response to tumor antigens may be regulated by using antisera with specificity for I-A determinants expressed on cells or possibly on factors of the host lymphoid system.