DNA sequence analysis of spontaneous mutations in the SUP4-o gene of Saccharomyces cerevisiae.
Open Access
- 1 February 1988
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 8 (2) , 978-981
- https://doi.org/10.1128/mcb.8.2.978
Abstract
A collection of 196 spontaneous mutations in the SUP4-o gene of the yeast Saccharomyces cerevisiae was analyzed by DNA sequencing. The classes of mutation identified included all possible types of base-pair substitution, deletions of various lengths, complex alterations involving multiple changes, and insertions of transposable elements. Our findings demonstrate that at least several different mechanisms are responsible for spontaneous mutagenesis in S. cerevisiae.This publication has 19 references indexed in Scilit:
- Development of a yeast system to assay mutational specificityMutation Research/Environmental Mutagenesis and Related Subjects, 1987
- THE STRUCTURE AND FUNCTION OF YEAST CENTROMERESAnnual Review of Genetics, 1985
- Spontaneous mutagenesis: the roles of DNA repair, replication, and recombinationMutation Research/Reviews in Genetic Toxicology, 1985
- Rapid and reliable dideoxy sequencing of double-stranded DNAGene, 1985
- The promoter sequence of a yeast tRNAtyr geneCell, 1983
- Unique Self-complementarity of Palindromic Sequences Provides DNA Structural Intermediates for MutationCold Spring Harbor Symposia on Quantitative Biology, 1983
- Transposable Elements (Ty) in YeastCold Spring Harbor Symposia on Quantitative Biology, 1981
- The yeast transposon Ty1 generates duplications of target DNA on insertionNature, 1980
- Mutations at the yeast SUP4 tRNATyr locus: DNA sequence changes in mutants lacking suppressor activityPublished by Elsevier ,1980
- Transcription and processing of intervening sequences in yeast tRNA genesCell, 1978