THE INFLUENCE OF SOMATOTROPIN AND CORTICOTROPIN ON THE ISLETS OF LANGERHANS OF THE RAT1

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Abstract
A somatotropic prepn. which increased body wt. and N retention in adult female rats force-fed a moderate carbohydrate diet, did not affect significantly the size of the islets of Langerhans nor the cytology of the beta cells. A corticotropic prepn. increased the number and size of the islets, and induced enlargement and degranulationa cells. yria occurred in some animals, and when present at autopsy, was accompanied by cytological evidence of the most intense beta cell stimulation. Concurrent admn. of somatotropic and corticotropic prepns. induced variable effects on the islets. Some increase in size of the alpha cells was brought about by both prepns.