Variable susceptibility of mice to group B coxsackievirus infections

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Abstract
Laboratory strains of group B coxsackievirus serotypes 1-6 were inoculated intraperitoneally into newborn mice of differing genetic backgrounds. Of the 4 genetic strains investigated, C3H mice appeared to be resistant to all 6 serotypes, whereas BALB/c mice were most susceptible. Swiss mice and a random-bred Swiss strain (COH) were intermediate in susceptibility. The findings underscore the fact that clinical isolation attempts and experimental studies involving group B coxsackieviruses must take into account both the virus strain used and the genetic background of the host. For clinical isolation of these viruses, the BALB/c mouse may be the most suitable of the strains tested.