EFFECT OF INDOMETHACIN AND SODIUM MECLOFENAMATE ON RENAL CONCENTRATING DEFECT IN EXPERIMENTAL ENTEROCOCCAL PYELONEPHRITIS IN RATS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 88  (6) , 958-964
Abstract
A severe urinary concentrating defect early in the course of experimental enterococcal [Staphylococcus aureus and Escherichia coli] pyelonephritis [in rats] was confirmed. This defect in maximum concentrating ability was almost completely reversed immediately following indomethacin or sodium meclofenamate i.v. This effect of indomethacin and sodium meclofenamate was transient and was not associated with a fall in numbers of enterococci/g of kidney. Injection of indomethacin or sodium meclofenamate in noninfected rats had no effect on maximum renal concentrating ability. The potential mechanisms by which indomethacin and sodium meclofenamate, inhibitors of renal prostaglandin synthesis, could reverse a defect in maximum urinary concentration are discussed.

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