Increased β‐aminoisobutyric acid in rat liver with 6‐azauracil and its enantiomer
Open Access
- 21 October 1985
- journal article
- Published by Wiley in FEBS Letters
- Vol. 191 (1) , 113-116
- https://doi.org/10.1016/0014-5793(85)81004-8
Abstract
When 6‐azauracil was subcutaneously injected, β‐aminoisobutyric acid and β‐alanine contents were increased 22 and 61‐fold, respectively, in rat liver. Incorporation of [methyl‐14Cithymine into β‐aminoisobutyric acid was increased to 42‐fold by 6‐azauracil treatment. The absolute configuration of this amino acid was proved to be the (R)‐form by means of a gas‐chromatographic technique. 6‐Azauracil inhibited β‐alanine‐pyruvate aminotransferase activity with an I 50 of approx. 2.5 mM.Keywords
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