Rectal absorption of bacampicillin in rabbits.

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Abstract
In this study, the rectal absorption of bacampicillin hydrochloride (BAPC) in rabbits as a model was investigated with the aim of preparing efficacious suppositories. First, analytical methods, were develped to determine penicillins in plasma for evaluating the absorption of BAPC. When BAPC was mixed in the plasma, BAPC was not detected only ampicillin (ABPC) derived from BAPC was detected by high performance liquid chromatographic analysis. The bioavailability of BAPC was studied following oral and rectal administration in rabbits. Administration of a BAPC suppository formulated with Witepsol H-15 produced absorption at a level 80% of that found after oral dosing, whereas no measurable level was seen following rectal administration of an ABPC suppository corresponding to the BAPC dose. Further, rectal absorption of BAPC increased with increasing dose of a prolonged plasma level was observed.