The thioredoxin system—From science to clinic
- 21 October 2003
- journal article
- review article
- Published by Wiley in Medicinal Research Reviews
- Vol. 24 (1) , 40-89
- https://doi.org/10.1002/med.10051
Abstract
The thioredoxin system—formed by thioredoxin reductase and its characteristic substrate thioredoxin—is an important constituent of the intracellular redox milieu. Interactions with many different metabolic pathways such as DNA‐synthesis, selenium metabolism, and the antioxidative network as well as significant species differences render this system an attractive target for chemotherapeutic approaches in many fields of medicine—ranging from infectious diseases to cancer therapy. In this review we will present and evaluate the preclinical and clinical results available today. Current trends in drug development are emphasized. © 2003 Wiley Periodicals, Inc. Med Res Rev, 24, No. 1, 40–89, 2004Keywords
This publication has 313 references indexed in Scilit:
- Nuclear transcription factor-κB as a target for cancer drug developmentLeukemia, 2002
- The pathogenic basis of malariaNature, 2002
- PeroxiredoxinsBiological Chemistry, 2002
- Nucleoredoxin, Glutaredoxin, and Thioredoxin Differentially Regulate NF-κB, AP-1, and CREB Activation in HEK293 CellsBiochemical and Biophysical Research Communications, 2000
- A thioredoxin reductase-class of disulphide reductase in the protozoan parasite Giardia duodenalisMolecular and Biochemical Parasitology, 1996
- Life with 6000 GenesScience, 1996
- Calmodulin structure refined at 1.7 Å resolutionJournal of Molecular Biology, 1992
- Possible regulation of the in vitro assembly of bovine brain tubulin by the bovine thioredoxin systemBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1991
- Calcium regulates thioredoxin reductase in human metastatic melanomaBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1989
- A thioredoxin — Thioredoxin reductase system from rat tumorBiochemical and Biophysical Research Communications, 1967