A Route to Annulated Indoles via a Palladium-Catalyzed Tandem Alkylation/Direct Arylation Reaction
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- 1 September 2005
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 127 (38) , 13148-13149
- https://doi.org/10.1021/ja054472v
Abstract
A norbornene-mediated palladium-catalyzed tandem alkylation/C−H functionalization sequence is described, in which an alkyl−aryl bond and a heteroaryl−aryl bond are formed in one pot. A variety of highly substituted six- and seven-membered ring annulated indoles were synthesized in good yields from bromoalkyl indoles and aryl iodides.Keywords
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