A Concise Synthesis of a Novel Antiangiogenic Tyrosine Kinase Inhibitor
- 23 November 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 70 (1) , 175-178
- https://doi.org/10.1021/jo048334k
Abstract
An efficient synthesis of the potent KDR inhibitor 3-[5-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-1H-indole-2-yl]quinolin-2(1H)-one (1) is described. The process features a noncryogenic indole boronation and a dicyclohexylamine-mediated Suzuki coupling.Keywords
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