Urinary porphyrins in lead-treated rabbits

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Abstract
The porphyrins present in the urine of Pb-treated rabbits were examined chromatographically. The chief porphyrin present was coproporphyrin III. Coproporphyrin I was not convincingly demonstrable in any of the material, and, if present, constituted a very small fraction of the total. Evidence was obtained for the presence also of porphyrins containing 2, 3, 6 and perhaps 5 carboxyl groups. It is suggested that the tri- and hexa-carboxylic porphyrins exist in 2 position-isomeric forms. Evidence was also obtained for the presence of another tetracarboxylic porphyrin not identical with coproporphyrin I or III.