Synthesis of colchifoline from deacetylcolchiceine

Publisher Website
Google Scholar
Abstract
Treatment of a mixture of deacetylcolchicine and deacetylisocolchicine, obtained by diazomethane methylation of deacetylcolchiceine, with trifluoroacetylglycolyl chloride in pyridine, afforded directly colchifoline and isocolchifoline. The two ether isomers could be separated by chromatography and the material eluted first proved to be identical with colchifoline isolated from commercial samples of colchicine.